➔ Slides
AuthorsEric Rivals,
Institute of Computational BiologyAbstractCore biological objects, such as DNA, RNA, proteins or epigenomic marks are modeled as discrete structures (e.g., sequence, structures, motifs, etc), and their interactions are viewed as discrete connections that formed important networks (e.g., the regulatory network where genes are logically connected with the genes that control their expression through binding at a precise location in their promoter or enhancer region). Thus, many biological systems and processes can be investigated through computational methods, which intrinsically target digital structures. The development of life sciences more and more requires the design of computational solutions (algorithms, models, data structures, etc). To match this need, the
IBC was launched in 2012 to foster and catalyze multidisciplinary research on computational approaches for life sciences. The IBC gathers more than 100 researchers from 13 institutions of Montpellier area (and beyond), at the nexus of life sciences, computer science, and mathematics.
The wealth of data acquired in biology projects using recent technologies, like high throughput sequencing or imaging techniques, also demands for efficient and scalable bioinformatic tools.
Hence, IBC researchers aim at designing algorithms, pipelines, models, inference methods, databases for tackling key computational questions at large scales such as image processing, sequence analysis, evolutionary inferences, structural modeling or data integration. Computational solutions are then applied to investigate multiple biological issues: like the control of gene expression, genome assembly, evolutionary or developmental questions, related to a wide variety of biological models from HIV to worms, algae, pathogens, plants (like rice) or other eukaryotic species.
In this presentation, i will give an overview of some computational developments and biological applications that have been investigated in the last five years at the IBC.
IBC is accredited and supported by eight national trustees: CNRS, INRA, INSERM, INRIA, IRD, CIRAD, SupAgro, and of course the Université de Montpellier, which hosts the IBC in a building of St Priest Campus.